Circadian rhythms

Health culture: Balance and longevity

Aging is a program

«Senescence is an evolutionary “program” in the “homo sapiens” mammal’s brain, just like growth,

puberty and fertility.»

W. Pierpaoli

Aging and melatonin are linked by a mutual interdependence.

Aging is a precise hormonal-neuroendocrine program, genetically created and unique for each species. It is a program found in the “pineal reticulum”, or rather in the brain’s and peripheral nervous system’s structures that regulate circadian synchronous synthesis and secretion (day/night), the oscillating-rhythm of all hormones, neuropeptides and all other endogenous molecules in the body that closely follow planetary and solar rhythms.


The aging


The aging program, similar to that of growth, puberty and fertility, follows a path, that is independent of so-called aging-associated diseases.

The expression of typical aging-associated diseases, such as metabolic syndrome x (“the deadly quartet”, i.e. hypertension, hyperglycemia, hypertriglyceridemia and upper body obesity) do not depend on and are not a consequence of aging, but rather of an alteration and desynchronization of day/night-time hormonal cycles.
Circadian hormonal synchronization can be altered by disease, and by endogenous and exogenous factors that flatten youthful hormonal rhythms: mental and social stress factors, a hereditary tendency towards enzymatic and metabolic alterations, acute and chronic bacterial and viral infections, nutritional habits and deficiencies, environmental life conditions, toxic agents, contaminations, various types of radiation and much more too.


Reprogramming aging with melatonin

«To age or not to age, that is the question.»

W. Pierpaoli

As a programmed hormonal event, the aging program may be changed and reversed through a reprogramming strategy. However, on the condition that we have sufficient knowledge about basic aging biology. We have proven that by inducing the night-time melatonin peak in the pineal gland through night-time administration, it is possible to delay aging and the accompanying diseases. However, when we state that aging and melatonin are linked by an interdependent relationship, we are not saying that melatonin in itself is a final remedy for anti-aging interventions. In fact, a pineal gland transplant from a young animal to an old animal produces marked rejuvenation effects in melatonin.
These effects do not depend on the production of melatonin, but on the transplanted pineal gland.


The role of melatonin

Other molecules reproduce the anti-aging effects of melatonin more rapidly.

Therefore, we believe that the purpose of melatonin is to protect the pineal gland from aging, and to maintain its functions, that can produce other molecules that can rapidly reharmonize with young values. What is meant by cyclical hormonal clock.


Resynchronizing cycles

By resynchronizing hormonal clock cycles, permanent reconstitution of immune surveillance and maintenance of health and the body’s biological integrity is obtained. By trying to understand how aging and melatonin were related, we uncovered the basis on which nature and evolution have built and maintain the biological integrity of every living creature.
The foundation of health is therefore built on maintaining a youthful hormonal cycle.