How can we live and what regulates our organism’s balance and good working order, to stay in good health? 

We have a biological clock that regulates our body functions while respecting circadian (day/night) and seasonal (the changes in temperature and length of daytime) rhythms and the environment in which we live (condition and lifestyle). It controls the sequence of our life stages: growth, fertility, ageing which then also lead us to death: it is our pineal gland.

This biological clock also influences the immune system.

Help immune defenses

The pineal gland regulates biological balance


Our life programs are managed by the pineal gland that acts as the conductor for all our body functions and keeps our bodies’ hormonal rhythms in sync.

«Realising the importance of maintaining adaptation and synchronization (link a Homepage/ Synchronization and Health) in line with the Cosmos’ rhythms is the first step towards protecting our health and longevity». 


Walter Pierpaoli

How does the pineal gland carry out this delicate, yet complex task?

Professor Pierpaoli explains it to us:

“Melatonin guides the cells in doing everything required to keep the body running like the highly efficient machine it is”.

So, melatonin is the communication tool, the messenger that the pineal gland uses, through the production of the nocturnal melatonin peak, to issue its instructions to the body’s various systems and to maintain health.

Illnesses are the consequence and expression of this synchronicity being altered.

“Health is the most important thing” is a universal principle that has always guided Professor Pierpaoli’s research. His in-depth studies of the pineal gland and the immune system have focused on two fundamental molecules: melatonin and zinc.


Two molecules that are the immune system’s friends…


Melatonin, thanks to its indirect action on the neuroendocrine system that controls the immune response, acts as the antagonist of immunosuppression. It therefore brings about the effect of supporting the immune system, which starts doing its job once again, i.e. defending the organism from attacks by external pathogens. This emerged from the results of experiments carried out by Professor Pierpaoli on immunodepressed mice.

Zinc contributes to supporting the immune system’s function. It is a precious element for the body as it is an active element in the synthesis of more than 200 enzymes that are vital for essential cell functions. Zinc is also found in high concentrations in the pineal gland.

…that we may be deficient in

Current lifestyles have distanced us from natural rhythms. For example, artificial light, both illumination and the especially damaging light from electronic equipment, to which we are all exposed until late in the evening, interferes with the pineal gland’s task. Without darkness, the pineal gland does not function physiologically.

As we age, zinc absorption from food sources is also constantly decreasing. At an advanced age, in fact, the balance between the levels of absorbed zinc and zinc used by the body turns negative. Studies have shown that zinc is essential for supporting functional recovery, especially in older people.


The harmony of biological rhythms is our immune system’s best ally.


As the cold season arrives, the body is naturally more exposed to external attacks, and that is why we must absolutely reinforce our immune system. We have several tools to allow us to do that, for example maintaining the harmony of our biological rhythms by trying to change a few bad habits, replacing them with other, healthier ones. 


1.Maestroni G., Conti A. and Pierpaoli W. Role of the pineal gland in immunity. Circadian synthesis and release of the pineal melatonin modulates the antibody response and antagonizes the immunosuppressive effect of corticosterone. J. Neuroimmunol. 13, 19-30, 1986

2.Maestroni G., Conti A. and Pierpaoli W. The pineal gland and the circadian, opiatergic, immunoregulatory role of melatonin. Ann. N.Y. Acad. Sci. 496, 67-77, 1987

3.Maestroni, G., Conti, A. and Pierpaoli, W. The pineal gland and the circadian, opiatergic, immunoregulatory role of melatonin. Ann. N.Y. Acad. Sci. 496, 67-77, 1987

4..Maestroni G., Conti A. and Pierpaoli W. Role of the pineal gland in immunity. II. Melatonin enhances the antibody response via an opiatergic mechanism. Clin. Exp. Immunol. 68, 384-391, 1987.

5.Maestroni G., Conti A. and Pierpaoli W. Role of the pineal gland in immunity. III. Melatonin antagonizes the immunosuppressive effect of acute stress via an opiatergic mechanism. Immunology 63, 465-469, 1988.

6.Maestroni G., Conti A. and Pierpaoli W. Pineal melatonin, its fundamental immunoregulatory role in aging and cancer. Ann. N.Y. Acad. Sci. 521, 140-148, 1988.