Protect and rest the Pineal Gland, helping it regenerate and to slow down aging.
laboratory research and clinical trials on melatonin, the Pineal Gland and aging mechanisms of aging of the
Hypothalamus-Pituitary-Pineal brain circuit.
The fact is that melatonin has no quantitative pharmacological value at all, as demonstrated in hundreds of
scientific journals. It resynchronizes the biological rhythms that control hormones and immunity by working on the
pineal gland. The pineal gland, which regulates the cyclic production of the hormones of our body, produces
melatonin, and as we age it produces less and less. In fact, the flat line and disappearance of the nocturnal
peak of melatonin, other than the constant drop in blood zinc levels are specific signs
that the organism is aging and the deterioration of the hormonal control of our essential functions. Therefore,
it is necessary to reverse this trend in order to maintain the nocturnal peak of melatonin, typical of youth, constant
and, therefore, helps individuals recover that youthful message that is essential to maintain the pineal
gland at the state is which it was during youth, i.e. between 15 and 20 years of age. The reason why our
formula was developed with the intention of reproducing within the body that type of nocturnal peak of
melatonin produced by the Pineal Gland between one and three a.m., which imitates the physiological youthful
nocturnal peak. Since the pineal gland produces melatonin only at night, giving your body
Melatonin Zn-Se at night, which produces the correct release of the nocturnal melatonin peak, you protect and put to rest the
Pineal Gland, which must not produce melatonin with a very complex synthesis. Therefore,
we help the Pineal Gland to regenerate and maintain itself in a youthful state and, therefore, produce molecules that
regulate the entire hormonal system, also called neuroendocrine, resulting in the normalization of
immunological, metabolic and endocrine functions, as well as slowing down aging (which is certainly a clear process
that is genetically programmed in the brain, but which manifests itself through hormonal regulation).
This is precisely the true physiological value of taking Pierpaoli’s Melatonin! So, if there is a
dismantling of the biological rhythms of the body, taking Melatonin Zn-Se helps to renovate the internal
For this purpose, the 1 mg dose in Pierpaoli’s Melatonin tablets is more than sufficient. It has, in fact
been proven that a dose of 0.3 mg of melatonin in tablet form is already sufficient to increase the level of melatonin
in blood about 120 picograms per milliliter, a level that corresponds to the youthful nocturnal peak of melatonin.
Administering 0.3 mg doses of melatonin to adult males will result in blood levels close to physiological levels.
It should, however, be considered that individual needs may vary according to differences in
metabolism. Precisely because everybody has a different intestinal absorption, Prof. Pierpaoli
prudentially suggests taking 1 to 3 mg., given that up to certain levels there is no risk of overdose.
Pierpaoli W. and Regelson W. with Carol Colman.
The Melatonin Miracle. Nature’s Age-Reversing, Disease-Fighting, Sex-Enhancing Hormone.
Simon & Schuster, New York, 1995 (tradotto in 17 lingue).
Pierpaoli W., N.H. Spector, Editors.
Neuroimmunomodulation: Interventions in Aging and Cancer. First Stromboli Conference on Aging and Cancer.
Ann. N.Y. Academy Sci., 521, 1988.
Pierpaoli W., Editor.
Reversal of Aging. Fourth Stromboli Conference on Aging and Cancer.
Ann. N.Y. Acad. Sci. 1057, 2005.
Pierpaoli W., Dall’Ara A., Pedrini, E. and Regelson W.
The pineal control of aging. The effects of melatonin and pineal grafting on the survival of older mice. Second Stromboli Conference on Aging and Cancer, June 1990.
Ann. N.Y. Acad. Sci. 621: 291-313, 1991.
Pierpaoli W. and Lesnikov V.A.
The pineal aging clock. Evidence, models, mechanisms, interventions. The Aging Clock. Third Stromboli Conference on Agingand Cancer, June 1993.
Ann. N.Y. Acad. Sci. 719: 461-473, 1994.
Pierpaoli W. and Regelson W.
Pineal control of aging: effect of melatonin and pineal grafting on aging mice.
Proc. Natl. Acad. Sci. USA, 94: 787-791, 1994.
Mocchegiani E., Bulian D., Santarelli L., Tibaldi A., Muzzioli M., Pierpaoli W. and Fabris N.
The immuno-reconstituting effect of melatonin or pineal grafting and its relation to zinc pool in aging mice.
J. Neuroimmunol. 53: 189-201, 1994.
Mocchegiani E., Bulian D., Santarelli L., Tibaldi A., Muzzioli M., Lesnikov V., Pierpaoli W. and Fabris N.
The zinc pool is involved in theimmunoreconstituting effect of melatonin in pinealectomized mice.
J. Pharmac. & Exp. Therap. 277: 1200-1208, 1996.
Mocchegiani E., Bulian D., Santarelli L., Tibaldi A., Pierpaoli W. and Fabris N.
The zinc-melatonin interrelationship. A working hypothesis. The Aging Clock. Third Stromboli Conference on Aging and Cancer, June 1993.
Ann. N.Y. Acad. Sci. 719: 298-307. 1994.
Pierpaoli W. and Lesnikov V.A.
Theoretical considerations on the nature of the pineal “aging clock”.
Gerontology 43: 20-25, 1997.
Bellipanni G., Bianchi P., Pierpaoli W., Bulian D. and Ilyia E.
Effects of melatonin in perimenopausal and menopausal women. A randomized and placebo controlled study.
Exp. Gerontol. 36, 297-310, 2001.
McGraw-Hill Book Company, New York, 1983.
V. M. Dilman
The Law of Deviation of Homeostasis and Diseases of Aging.
H.T. Blumenthal, Editor. John Wright PSG, Inc. Boston, 1981.
W. Pierpaoli and D. Bulian
The Pineal Aging and Death Program. I. Grafting of Old Pineals in Young Mice Accelerates their Aging.
J. Anti-Aging Med. 4, 31, 2001.
W. Pierpaoli, H.G. Kopp, J. Mueller and M. Keller
Interdependence between neuroendocrine programming and the generation of immune recognition in ontogeny.
Cell. Immunology 29, 16, 1977.
Irina V. Zhdanova, Richard J. Wurtman, Aygul Balcioglu, Alex I. Kartashov and Harry J. Lynch + Author
Affiliations Department of Brain and Cognitive Sciences.
Massachusetts Institute of Technology.